Survival Analysis of Breast Cancer Patients Using Accelerated Failure Time (AFT) Model: A Parametric Approach
DOI:
https://doi.org/10.13052/jrss0974-8024.19219Keywords:
Breast cancer, AFT model, AIC, BICAbstract
The primary objective of this study is to identify which covariates of breast cancer patients increase or decrease survival time. The study includes 802 breast cancer patients and during the study period 157 deaths occurred and 645 cases are censored. In this study, four parametric accelerated failure time models are used to identify the best-fitting model: exponential AFT, Weibull AFT, Lognormal AFT, and Log-logistic AFT. To determine the best-fitting model, the Akaike Information Criterion (AIC) and the Bayesian Information Criterion (BIC) are used. The lowest AIC and BIC values indicate the best-fitting model. The mean age of the breast cancer patients was 47.5 ± 11.008 years. The overall 5 year survival rate of breast cancer patients was 21%. In this study, we found that the Log-Logistic AFT model best fits the breast cancer data set. The AFT model is an alternative to Cox proportional hazard model. In an AFT model, the effect of covariates accelerates or decelerates the time to the event of interest.
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