Left-Handed Metamaterial Lens Applicator with Built-in Cooling Feature for Superficial Tumor Hyperthermia

Authors

  • Yonghui Tao Department of Electronic and Information Engineering Jinling Institute of Technology, Nanjing, 211169, China
  • Erfu Yang Space Mechatronic Systems Technology Laboratory (SMeSTech), Strathclyde Space Institute Department of Design, Manufacture and Engineering Management, University of Strathclyde 704 James Weir Building, 75 Montrose Street, Glasgow G1 1XJ, United Kingdom
  • Gang Wang Key Laboratory of Electromagnetic Space Information Department of Electronic Engineering and Information Science University of Science and Technology of China, Hefei, 230026, China

Keywords:

Hyperthermia, metamaterial lens, microwave, tumor, water bolus

Abstract

In all hyperthermia schemes with lefthanded metamaterial (LHM) lens applicator, water bolus are used to prevent skin from being overheated during the hyperthermia treatment. Owing to water’s high refraction index, high reflection usually occurs at the interface between low-index LHM lens and water bolus, and between water and skin, which will lead to the low efficiency of hyperthermia. In this paper, we propose a new LHM lens applicator with built-in cooling feature for superficial tumor hyperthermia. Both simulation and experiment demonstrated that microwave hyperthermia with the proposed applicator may concentrate more microwave energy into deeper tissue if compared to hyperthermia with normal LHM lens.

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References

E. Jones, J. Oleson, L. Prosnitz, T. Samulski, Z. Vujaskovic, D. Yu, L. Sanders, and M. Dewhirst, “Randomized trial of hyperthermia and radiation for superficial tumors,” J. Clinical Oncol., vol. 23, pp. 3079-3085, 2005.

J. B. Pendry, “Negative refraction makes a perfect lens,” Phys. Rev. Lett., vol. 85, pp. 3966-3969, 2000.

K. Aydin, I. Bulu, and E. Ozbay, “Subwavelength resolution with a negative-index metamaterial superlens,” Appl. Phys. Lett., vol. 90, pp. 254102, 2007.

J. Zhu and G. Eleftheriades, “Experimental verification of overcoming the diffraction limit with a volumetric Veselago-Pendry transmission-line lens,” Phy. Rev. Lett., vol. 101, pp. 013902, 2008.

A. K. Iyer and G. V. Eleftheriades, “Mechanisms of subdiffraction free-space imaging using a transmission-line metamaterial superlens: An experimental verification,” Appl. Phys. Lett., vol. 92, pp. 131105, 2008.

S. Rudolph, C. Pfeiffer, and A. Grbic, “Design and free-space measurements of broadband, lowloss negative-permeability and negative-index media,” IEEE Trans. Antennas Propagat., vol. 59, pp. 2989-2997, Aug. 2011.

G. Wang and Y. Gong, “Metamaterial lens applicator for microwave hyperthermia of breast cancer,” Int. J. Hyperthermia, vol. 25, pp. 434- 455, 2009.

Y. Gong and G. Wang, “Superficial tumor hyperthermia with flat left-handed metamaterial lens,” Prog. Electromagn. Res., vol. 98, pp. 389-405, 2009.

M. Velazquez-Ahumada, M. Freire, and R. Marque, “Metamaterial focusing device for microwave hyperthermia,” Microw. Opt. Tech. Lett., vol. 53, pp. 2868-2872, 2011.

Y. Tao and G. Wang, “Hyperthermia of large superficial tumor with a flat LHM lens,” IEEE MTT-S International Microwave Symposium, pp. 1-3, 2012.

Y. Tao and G. Wang, “Conformal hyperthermia of superficial tumor with left-handed metamaterial lens applicator,” IEEE Trans. Biomed. Eng., vol. 59, no. 12, pp. 3525-3530, 2012.

S. Rudolph, C. Pfeiffer, and A. Grbic, “Design and free-space measurements of broadband, lowloss negative-permeability and negative-index media,” IEEE Trans. Antennas Propagat., vol. 59, pp. 2989-2997, Aug. 2011.

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Published

2021-07-30

How to Cite

[1]
Yonghui Tao, Erfu Yang, and Gang Wang, “Left-Handed Metamaterial Lens Applicator with Built-in Cooling Feature for Superficial Tumor Hyperthermia”, ACES Journal, vol. 32, no. 11, pp. 1029–1034, Jul. 2021.

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