Towards Wideband Hyperthermia Treatment System

Authors

  • N. Nizam-Uddin Department of Electrical Engineering King Saud University, Riyadh, Kingdom of Saudi Arabia
  • Wazie Alkadri Department of Electrical Engineering King Saud University, Riyadh, Kingdom of Saudi Arabia
  • Waqar Ahmad Malik Department of Electrical Engineering King Saud University, Riyadh, Kingdom of Saudi Arabia
  • Ibrahim Elshafiey Department of Electrical Engineering King Saud University, Riyadh, Kingdom of Saudi Arabia
  • Abdel Fattah Sheta Department of Electrical Engineering King Saud University, Riyadh, Kingdom of Saudi Arabia

Keywords:

Big data, double-ridge horn antenna, hyperthermia treatment, time reversal focusing, wideband power amplifier

Abstract

This paper presents an overview of design and functionality of the essential modules proposed to build a wideband hyperthermia system. Description is provided of the waveform shaper, power amplifier and applicator array modules. Big data analysis is presented to accelerate energy localization depending on a time reversal technique. Simulation results are provided assuming a cylindrical head phantom characterized with wideband dispersive tissue properties, and the obtained field maps are shown in different planes to visualize energy localization process. Results reveal that wideband operation has the potential to enhance energy localization in deep tumor regions while eradicating hot spots, as compared to conventional narrowband systems.

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References

A. Shitzer and R. C. Eberhart, Heat Transfer in Medicine and Biology: Analysis and Applications. vol. 1, Plenum Press, 1985.

H. Trefna and M. Persson, “Heating of deep seated tumours using microwaves radiation,” in ACES, Verona, Italy, 2007.

X. Wu, B. Liu, and B. Xu, “Theoretical evaluation of high frequency microwave ablation applied in cancer therapy,” Applied Thermal Engineering, vol. 107, pp. 501-507, 2016.

J. Mallorqui, A. Broquetas, L. Jofre, and A. Cardama, “Non-invasive active thermometry with a microwave tomographic scanner in hyperthermia treatments,” Applied Computational Electromagnetics Society (ACES) Journal, vol. 7, pp. 121-127, 1992.

M. M. Paulides, P. R. Stauffer, E. Neufeld, P. F. Maccarini, A. Kyriakou, R. A. Canters, C. J. Diederich, J. F. Bakker, and G. C. Van Rhoon, “Simulation techniques in hyperthermia treatment planning,” International Journal of Hyperthermia, vol. 29, pp. 346-357, 2013.

S. Fodeh and Q. Zeng, “Mining big data in biomedicine and health care,” Journal of Biomedical Informatics, vol. 63, p. 400, 2016.

K. J. Archer, K. Dobbin, S. Biswas, R. S. Day, D. C. Wheeler, and H. Wu, “Computer simulation, bioinformatics, and statistical analysis of cancer data and processes,” Cancer Informatics, vol. 14, p. 247, 2015.

J. Roski, G. W. Bo-Linn, and T. A. Andrews, “Creating value in health care through big data: Opportunities and policy implications,” Health Affairs, vol. 33, pp. 1115-1122, 2014.

P. Groves, B. Kayyali, D. Knott, and S. V. Kuiken, “The ‘big data’ revolution in healthcare: Accelerating value and innovation,” Center for US Health System Reform, McKinsey & Company, 2013.

M. Converse, E. J. Bond, B. Veen, and S. C. Hagness, “A computational study of ultra-wideband versus narrowband microwave hyperthermia for breast cancer treatment,” IEEE Transactions on Microwave Theory and Techniques, vol. 54, pp. 2169-2180, 2006.

M. N. Tabassum, I. Elshafiey, and M. Alam, “Enhanced noninvasive imaging system for dispersive highly coherent space,” in IEEE International Conference on Acoustics, Speech and Signal Processing (ICASSP), pp. 912-916, 2015.

M. N. Tabassum, I. Elshafiey, and M. Alam, “Efficient techniques to enhance nearfield imaging of human head for anomaly detection,” in IEEE International Symposium Medical Measurements and Applications (MeMeA), pp. 565-569, 2015.

M. N. Tabassum, I. Elshafiey, and M. Alam, “Compressed sensing based nearfield electromagnetic imaging,” in IEEE International Conference on Control System, Computing and Engineering (ICCSCE), pp. 571-575, 2014.

M. Aldhaeebi and I. Elshafiey, “New antenna design for hyperthermia treatment of human head,” in IEEE 16th International Conference on Computer Modelling and Simulation, UKSim-AMSS, 2014, pp. 96-100.

A. Alkhaibari, A. F. Sheta, and I. Elshafiey, “Notched anti-podal Vivaldi antenna for biomedical applications,” in IEEE 7th International Conference on Modeling, Simulation, and Applied Optimization (ICMSAO), pp. 1-4, 2017.

M. M. M. Ali, O. Haraz, I. Elshafiey, S. Alshebeili, and A.-R. Sebak, “Efficient single-band and dualband antennas for microwave imaging and hyperthermia treatment of brain tumors,” in IEEE International Conference on Control System, Computing and Engineering (ICCSCE), pp. 597- 600, 2014.

G. Chakaravarthi and K. Arunachalam, “Design and characterisation of miniaturised cavity-backed patch antenna for microwave hyperthermia,” International Journal of Hyperthermia, vol. 31, pp. 737-748, Mar. 10, 2015.

S. Singh and S. P. Singh, “Theoretical and simulation studies on water-loaded metal diagonal horn antenna for hyperthermia application,” Progress In Electromagnetics Research C, vol. 58, pp. 105-115, 2015.

A. Mallahzadeh and A. Imani, “Modified doubleridged antenna for 2-18 GHz,” Applied Computational Electromagnetics Society (ACES) Journal, vol. 25, p. 137, 2010.

Q. Yang, X. Zhao, and Y. Zhang, “Electromagnetic analysis on propagation characteristics of CRLH waveguide loaded with double ridge corrugations,” Progress In Electromagnetics Research C, vol. 75, pp. 1-11, 2017.

M. Botello-Perez, H. Jardon-Aguilar, and I. G. Ruíz, “Design and simulation of a 1 to 14 GHz broadband electromagnetic compatibility DRGH antenna,” in IEEE 2nd International Conference on Electrical and Electronics Engineering, pp. 118- 121, 2005.

S. I. Latif, D. Flores-Tapia, S. Pistorius, and L. Shafai, “Design and performance analysis of the miniaturised water-filled double-ridged horn antenna for active microwave imaging applications,” IET Microwaves, Antennas & Propagation, vol. 9, pp. 1173-1178, 2015.

H. Y. Amin and B. Yarman, “Distributed wideband power amplifier using reactive coupled line feedback structure,” in IEEE 2nd International Conference on Knowledge-Based Engineering and Innovation (KBEI), pp. 91-94, 2015.

S. Lin, M. Eron, and A. E. Fathy, “Development of ultra wideband, high efficiency, distributed power amplifiers using discrete GaN HEMTs,” IET Circuits, Devices & Systems, vol. 3, pp. 135-142, 2009.

A. Sayed, A. A. Tanany, and G. Boeck, “5W, 0.35- 8 GHz linear power amplifier using GaN HEMT,” in European Microwave Conference (EuMC), pp. 488-491, 2009.

Y. Ayasli, J. Vorhaus, R. Mozzi, and L. Reynolds, “Monolithic GaAs travelling-wave amplifier,” Electronics Letters, vol. 17, p. 413, 1981.

E. L. Ginzton, W. R. Hewlett, J. H. Jasberg, and J. D. Noe, “Distributed amplification,” Proceedings of the IRE, vol. 36, pp. 956-969, 1948.

Wolfspeed A Cree Company. 120 Watts RF GaN HEMT (CGH60120D). Available: http://www. wolfspeed. com/cgh60120d

A. J. Fenn, V. Sathiaseelan, G. A. King, and P. R. Stauffer, “Improved localization of energy deposition in adaptive phased-array hyperthermia treatment of cancer,” Lincoln Laboratory Journal, vol. 9, 1996.

C. M. Furse, “A survey of phased arrays for medical applications,” Applied Computational Electromagnetics Society (ACES) Journal, vol. 21, pp. 365-379, 2006.

S. Jacobsen and F. Melandsø, “The concept of using multifrequency energy transmission to reduce hot spots during deep-body hyperthermia,” Annals of Biomedical Engineering, vol. 30, pp. 34-43, 2002.

N. Nizam-Uddin and I. Elshafiey, “Transmission line approach for energy localization in wideband hyperthermia treatment system,” in IEEE 5th International Conference on Electronic Devices, Systems and Applications (ICEDSA), pp. 1-4, 2016.

N. Nizam-Uddin and I. Elshafiey, “Enhanced energy localization with wideband hyperthermia treatment system,” Applied Computational Electromagnetics Society Journal, vol. 32, pp. 389-396, 2017.

P. Takook, H. D. Trefná, A. Fhager, and M. Persson, “Evaluation of the 3D time reversal method for hyperthermia treatment planning in head and neck tumors,” in 9th European Conference on Antennas and Propagation (EuCAP), pp. 1-5, 2015.

H. D. Trefná, J. Vrba, and M. Persson, “Time reversal focusing in microwave hyperthermia for deep-seated tumors,” Physics in Medicine and Biology, vol. 55, p. 2167, 2010.

F. Bardati, A. Borrani, A. Gerardino, and G. A. Lovisolo, “SAR optimization in a phased array radiofrequency hyperthermia system,” IEEE Transactions on Biomedical Engineering, vol. 42, pp. 1201-1207, 1995.

C. A. Liontas and P. Knott, “An alternating projections algorithm for optimizing electromagnetic fields in regional hyperthermia,” in IEEE 10th European Conference on Antennas and Propagation (EuCAP), pp. 1-5, 2016.

R. M. C. Mestrom, J. P. van Engelen, M. C. van Beurden, M. M. Paulides, W. C. M. Numan, and A. G. Tijhuis, “A refined eigenvalue-based optimization technique for hyperthermia treatment planning,” in IEEE 8th European Conference on Antennas and Propagation (EuCAP), pp. 2010- 2013, 2014.

M. Aldhaeebi, M. Alzabidi, and I. Elshafiey, “Genetic algorithm optimization of SAR distribution in hyperthermia treatment of human head,” in IEEE 1st International Conference on Artificial Intelligence, Modelling and Simulation (AIMS), pp. 92-97, 2013.

M. Aldhaeebi, M. Alzabidi, and I. Elshafiey, “Optimization of UWB antenna array for hyperthermia treatment of brain tumor,” in IEEE Saudi International Electronics, Communications and Photonics Conference (SIECPC), pp. 1-6, 2013.

P. T. Nguyen, A. Abbosh, and S. Crozier, “Threedimensional microwave hyperthermia for breast cancer treatment in a realistic environment using particle wwarm optimization,” IEEE Transactions on Biomedical Engineering, 2016.

N. Nizam-Uddin and I. Elshafiey, “Enhanced energy localization in hyperthermia treatment based on hybrid electromagnetic and ultrasonic system: Proof of concept with numerical simulations,” BioMed Research International, vol. 2017, p. 18, 2017.

R. Carminati, R. Pierrat, J. De Rosny, and M. Fink, “Theory of the time reversal cavity for electromagnetic fields,” Optics Letters, vol. 32, pp. 3107- 3109, 2007.

D. Cassereau and M. Fink, “Time-reversal of ultrasonic fields. III. Theory of the closed timereversal cavity,” IEEE Transactions on Ultrasonics, Ferroelectrics, and Frequency Control, vol. 39, pp. 579-592, 1992.

MathWorks. MATLAB: The Language of Technical Computing. Available: http://www.mathworks.com/

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Published

2021-07-30

How to Cite

[1]
N. Nizam-Uddin, Wazie Alkadri, Waqar Ahmad Malik, Ibrahim Elshafiey, and Abdel Fattah Sheta, “Towards Wideband Hyperthermia Treatment System”, ACES Journal, vol. 32, no. 09, pp. 769–780, Jul. 2021.

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