Skip to main navigation menu Skip to main content Skip to site footer
International Journal of Translational Science

Articles

2024: Issue 2

What Could Explain Delay for Age-Reversal Clinical Trials?

DOI
https://doi.org/10.13052/ijts2246-8765.2024.024
Submitted
April 22, 2024
Published
2024-04-20

Abstract

This is a commentary article using data reported by the United States Drug Approval (FDA) system for clinical trials. The text surmised reasons for this delay. The data show continued delay to impact drugs reaching patients. Instead of increasing drug approval, the statistics showed a trend of increased numbers of drug on hold. The reason for these delays need to be evaluated, and perhaps to apply new technologies to evaluate the data.

References

  1. Prasad R. Building Breakthroughs: On the Frontier of Medical Innovation: JHU Press; 2022.
  2. Nightingale SL. Emerging Technologies and FDA Policy Formulation: The Impact of Government Regulation on Developing Drugs from New Technologies. Food Drug Cosm LJ. 1982;37:212.
  3. Wilson M. The US FDA and regulatory free fall. BMJ. 2023;380:p85.
  4. Sharfstein JM. Reform at the FDA – in need of reform. JAMA. 2020;323(2):123–4.
  5. Abraham J. Science, politics and the pharmaceutical industry: Controversy and bias in drug regulation: Taylor & Francis; 2023.
  6. Peixoto R, Pereira ML, Oliveira M. Beta-Blockers and Cancer: Where Are We? Pharmaceuticals (Basel). 2020;13(6).
  7. Fjæstad KY, Rømer AMA, Goitea V, Johansen AZ, Thorseth M-L, Carretta M, et al. Blockade of beta-adrenergic receptors reduces cancer growth and enhances the response to anti-CTLA4 therapy by modulating the tumor microenvironment. Oncogene. 2022;41(9):1364–75.
  8. Opie LH, Sonnenblick E, Frishman W, Thadani U. Beta-blocking agents. Drugs for the Heart. 1995;4.
  9. Thanapairoje K, Junsiritrakhoon S, Wichaiyo S, Osman MA, Supharattanasitthi W. Anti-ageing effects of FDA-approved medicines: a focused review. Journal of Basic and Clinical Physiology and Pharmacology. 2023;34(3):277–89.
  10. Rybina OY, Symonenko AV, Pasyukova EG. Compound combinations targeting longevity: Challenges and perspectives. Ageing Research Reviews. 2023;85:101851.
  11. Greco SJ, Ayer S, Guiro K, Sinha G, Donnelly RJ, Markos H, et al. Restoration of aged hematopoietic cells by their young counterparts through instructive microvesicles release. Aging (Albany NY). 2021;13(21):23981.
  12. Clark J. Challenging the Moral Authority of the FDA: A Lesson from History. 2020.

Downloads

Download data is not yet available.