Synthesis and Characterization of Novel MXeneCeria Heterostructure by Integration of Ti3C2Tx Quantum Dots into Fluorescent Nano-octahedral CeO2

Authors

  • Alireza Rafieerad 1) Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Department of Physiology and Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, Biomedical Engineering Program, University of Manitoba, Winnipeg, Manitoba R2H 2A6, Canada 2) Institute for Molecular Biosciences, Johann Wolfgang Goethe University Frankfurt am Main, 60438, Frankfurt, Germany
  • Soofia Khanahmadi Institute for Molecular Biosciences, Johann Wolfgang Goethe University Frankfurt am Main, 60438, Frankfurt, Germany
  • Sanjiv Dhingra Institute of Cardiovascular Sciences, St. Boniface Hospital Albrechtsen Research Centre, Department of Physiology and Pathophysiology, Max Rady College of Medicine, Rady Faculty of Health Sciences, Biomedical Engineering Program, University of Manitoba, Winnipeg, Manitoba R2H 2A6, Canada

DOI:

https://doi.org/10.13052/ijts2246-8765.2024.044

Keywords:

Ti3C2Tx-CeO2, stable nanocolloids, autofluorescent, surface titanium oxides, 0D/1D biomaterial

Abstract

Herein, we report the synthesis of a new stable zero/one-dimensional composite heterostructure “MXeneCeria” by integrating titanium carbide MXene (Ti3C2Tx) nanosheets-derived quantum dots with nano-octahedral particles of ceria (CeO2). This unique assimilation resulted in the formation of an auto-fluorescent aqueous colloidal material, which is detectable in fluorescent colors across various wavelengths, ranging from blue to green and red. The unique physicochemical properties of MXeneCeria make it a very promising nanocomposite and it may open a gateway to its potential applications in the biomedical field including tracking, immunoengineering, cell therapy, and targeted drug delivery.

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References

Dobrovolskaia, Marina A., and Scott E. McNeil. “Immunological Properties of Engineered Nanomaterials.” Nature Nanotechnology 2, no. 8 (2007): 469–78. https://doi.org/10.1038/nnano.2007.223.

Zheng, Yuanyuan, Xiangqian Hong, Jiantao Wang, Longbao Feng, Taojian Fan, Rui Guo, and Han Zhang. “2D Nanomaterials for Tissue Engineering and Regenerative Nanomedicines: Recent Advances and Future Challenges.” Advanced Healthcare Materials 10, no. 7 (2021): 2001743. https://doi.org/10.1002/adhm.202001743.

Chuang, Skylar T., Brandon Conklin, Joshua B. Stein, George Pan, and Ki-Bum Lee. “Nanotechnology-enabled immunoengineering approaches to advance therapeutic applications.” Nano Convergence 9, no. 1 (2022): 19. https://doi.org/10.1186/s40580-022-00310-0.

Sang, Wei, Zhan Zhang, Yunlu Dai, and Xiaoyuan Chen. “Recent advances in nanomaterial-based synergistic combination cancer immunotherapy.” Chemical Society Reviews 48, no. 14 (2019): 3771–3810. https://doi.org/10.1039/C8CS00896E.

Soleymaniha, Mohammadreza, Mohammad-Ali Shahbazi, Ali Reza Rafieerad, Aziz Maleki, and Ahmad Amiri. “Promoting role of MXene nanosheets in biomedical sciences: therapeutic and biosensing innovations.” Advanced healthcare materials 8, no. 1 (2019): 1801137. https://doi.org/10.1002/adhm.201801137.

Rafieerad, Alireza, Weiang Yan, Ahmad Amiri, and Sanjiv Dhingra. “Bioactive and trackable MXene quantum dots for subcellular nanomedicine applications.” Materials & Design 196 (2020): 109091. https://doi.org/10.1016/j.matdes.2020.109091.

Unal, Mehmet Altay, Fatma Bayrakdar, Laura Fusco, Omur Besbinar, Christopher E. Shuck, Süleyman Yalcin, Mine Turktas Erken et al. “2D MXenes with antiviral and immunomodulatory properties: A pilot study against SARS-CoV-2.” Nano Today 38 (2021): 101136. https://doi.org/10.1016/j.nantod.2021.101136.

Rafieerad, Alireza, Weiang Yan, Keshav Narayan Alagarsamy, Abhay Srivastava, Niketa Sareen, Rakesh C. Arora, and Sanjiv Dhingra. “Fabrication of smart tantalum carbide MXene quantum dots with intrinsic immunomodulatory properties for treatment of allograft vasculopathy.” Advanced Functional Materials 31, no. 46 (2021): 2106786. https://doi.org/10.1002/adfm.202106786.

Arora, Sumit, Jyutika M. Rajwade, and Kishore M. Paknikar. “Nanotoxicology and in vitro studies: the need of the hour.” Toxicology and applied pharmacology 258, no. 2 (2012): 151–165. https://doi.org/10.1016/j.taap.2011.11.010.

Ernst, Lena M., and Victor Puntes. “How Does Immunomodulatory Nanoceria Work? ROS and Immunometabolism.” Frontiers in immunology 13 (2022): 750175. https://doi.org/10.3389/fimmu.2022.750175.

Published

2025-02-05

How to Cite

Rafieerad, A. ., Khanahmadi, S. ., & Dhingra, S. . (2025). Synthesis and Characterization of Novel MXeneCeria Heterostructure by Integration of Ti3C2Tx Quantum Dots into Fluorescent Nano-octahedral CeO2. International Journal of Translational Science, 2024(04), 351–362. https://doi.org/10.13052/ijts2246-8765.2024.044

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