Advancing Science in Microgravity – Implications for Effective Therapies
DOI:
https://doi.org/10.13052/ijts2246-8765.2025.001Keywords:
Aerospace medicine, cancer, oncology, biomarker, organoid, space, microgravityAbstract
The International Space Station (ISS) is a collaborative platform for advanced research in microgravity, significantly contributing to cancer studies, drug development, and tissue engineering. Since its assembly in 1998, the ISS has become an invaluable environment for experiments not possible on Earth. A key focus is organoid development – miniature, 3D human organ models grown in space, offering insights into disease mechanisms, drug responses, and regenerative medicine. Microgravity promotes scaffold-free tissue formation, advancing neurodegenerative disease research and therapeutic discovery.
Cancer research on the ISS has expanded since the 2010s, using microgravity to grow 3D tumor models that mimic human tumors more accurately than Earth-based systems. These studies have improved our understanding of cancer cell behavior, chemotherapy resistance, and immune responses, driving new drug development. NASA’s collaboration with initiatives like the Cancer Moonshot accelerates cancer research in space.
Emerging biomarker studies in space are enhancing early cancer detection and environmental monitoring. Additionally, ISS research on radiation-induced DNA damage has led to improved diagnostic tools, such as microsatellite instability (MSI) tests, which aid in cancer detection and treatment planning. Overall, the ISS continues to push boundaries in biomedical research, offering novel insights that are transforming cancer biology, regenerative medicine, and precision health, with far-reaching implications for human health on Earth and beyond.
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References
J.L. Green, Space travel across the decades and beyond: A brief history of NASA’s space programme. J Physics: Conference Series, IOP Publishing, 2024, pp. 012046.
W.D. Compton, C.D. Benson, P. Dickson, Living and Working in Space: A NASA history of Skylab, Courier Corporation. 2011.
L.F. Belew, Skylab, our first space station, Scientific and Technical Information Office. Natl Aeronautics and Space. 1977.
A. Iwasaki, N. Ohgi, J. Tanii, T. Kawashima, H. Inada, Hyperspectral Imager Suite (HISUI)-Japanese hyper-multi spectral radiometer. IEEE Intl Geosci NSD remote sensing symposium, IEEE, 2011, pp. 1025–1028.
G. Rossi, A. Manfrin, M.P. Lutolf, Progress and potential in organoid research. Nature Rev Genetics, 19 (2018) 671–687.
M. Aguilar, G. Alberti, B. Alpat, A. Alvino, G. Ambrosi, K. Andeen, H. Anderhub, L. Arruda, P. Azzarello, A. Bachlechner, First Result from the Alpha Magnetic Spectrometer on the International Space Station: Precision Measurement of the Positron Fraction in Primary Cosmic Rays of 0.5–350 GeV. Physical Rev Lett, 110 (2013) 141102.
D. Dutta, I. Heo, H. Clevers, Disease modeling in stem cell-derived 3D organoid systems, Trends in molecular medicine, 23 (2017) 393–410.
M.A. Giulianotti, L.A. Low, Pharmaceutical research enabled through microgravity: perspectives on the use of the International Space Station US National Laboratory. Pharm Res, 37 (2020) 1–4.
G. Aleshcheva, J. Bauer, R. Hemmersbach, L. Slumstrup, M. Wehland, M. Infanger, D. Grimm, Scaffold-free tissue formation under real and simulated microgravity conditions. Basic & Clin Pharmacol Toxicol, 119 (2016) 26–33.
D. Marotta, L. Ijaz, L. Barbar, M. Nijsure, J. Stein, N. Pirjanian, I. Kruglikov, T. Clements, J. Stoudemire, P. Grisanti, Effects of microgravity on human iPSC-derived neural organoids on the International Space Station. Stem Cells Transl Med, 13 (2024) 1186–1197.
S. Ferraro, A. Dave, C. Cereda, E. Verduci, S. Marcovina, G. Zuccotti, Space research to explore novel biochemical insights on Earth. Clinica Chimica Acta, (2024) 119673.
A. Rangdal, A. Petryna, B. Shadpoor, L.S. Sherman, E. Homsi, A Theory of Gravitational Generation to Mitigate Space-Induced Low Gravity – Relevance to Premature Aging in Space. Intl J Transl Sci, 2024 (2024) 77–96.
E. Pavez Loriè, S. Baatout, A. Choukér, J.-I. Buchheim, B. Baselet, C. Dello Russo, V. Wotring, M. Monici, L. Morbidelli, D. Gagliardi, The future of personalized medicine in space: from observations to countermeasures. Frontiers Bioeng Biotechnol, 9 (2021) 739747.
F. Cialdai, A. Colciago, D. Pantalone, A.M. Rizzo, S. Zava, L. Morbidelli, F. Celotti, D. Bani, M. Monici, Effect of unloading condition on the healing process and effectiveness of platelet rich plasma as a countermeasure: Study on in vivo and in vitro wound healing models. Intl J Mol Sci, 21 (2020) 407.
F. Cialdai, L. Vignali, L. Morbidelli, A. Colciago, F. Celotti, A. Santi, A. Caselli, P. Cirri, M. Monici, Modeled microgravity affects fibroblast functions related to wound healing. Microgravity Sci Technol, 29 (2017) 121–132.
K. Strimbu, J.A. Tavel, What are biomarkers? Curr Opinion in HIV and AIDS, 5 (2010) 463–466.
C.A. Garcia, P. Suárez-Meade, M. Brooks, A.G. Bhargav, M.L. Freeman, L.M. Harvey, J. Quinn, A. Quiñones-Hinojosa, Behavior of glioblastoma brain tumor stem cells following a suborbital rocket flight: Reaching the “edge” of outer space. Microgravity, 9 (2023) 92.
N. Monti, M.G. Masiello, S. Proietti, A. Catizone, G. Ricci, A.H. Harrath, S.H. Alwasel, A. Cucina, M. Bizzarri, Survival pathways are differently affected by microgravity in normal and cancerous breast cells. Intl J Mol Sci, 22 (2021) 862.
X. Ma, J. Pietsch, M. Wehland, H. Schulz, K. Saar, N. Hübner, J. Bauer, M. Braun, A. Schwarzwälder, J. Segerer, Differential gene expression profile and altered cytokine secretion of thyroid cancer cells in space. FASEB J, 28 (2014) 813-835.
D.C. Berrios, J. Galazka, K. Grigorev, S. Gebre, S.V. Costes, NASA GeneLab: interfaces for the exploration of space omics data. Nucleic Acids Res, 49 (2021) D1515–D1522.
T.J. Corydon, H. Schulz, P. Richter, S.M. Strauch, M. Böhmer, D.A. Ricciardi, M. Wehland, M. Krüger, G.S. Erzinger, M. Lebert, Current knowledge about the impact of microgravity on gene regulation. Cells, 12 (2023) 1043.
M.S. Soares, R. Singh, S. Kumar, R. Jha, J. Nedoma, R. Martinek, C. Marques, The role of smart optical biosensors and devices on predictive analytics for the future of aquaculture systems. Optics & Laser Technol, 177 (2024) 111049.
M.J. Pecaut, X.W. Mao, D.L. Bellinger, K.R. Jonscher, L.S. Stodieck, V.L. Ferguson, T.A. Bateman, R.P. Mohney, D.S. Gridley, Is spaceflight-induced immune dysfunction linked to systemic changes in metabolism? PLoS One, 12 (2017) e0174174.
J. Kim, J.-H. Cheong, Role of mitochondria-cytoskeleton interactions in the regulation of mitochondrial structure and function in cancer stem cells. Cells, 9 (2020) 1691.
E. Harris, Cancer moonshot plan announced. J Am Med Assoc, 329 (2023) 1443–1443.
E. Rehnberg, K. Quaghebeur, B. Baselet, N. Rajan, T. Shazly, L. Moroni, S. Baatout, K. Tabury, Biomarkers for biosensors to monitor space-induced cardiovascular ageing. Frontiers in Sensors, 4 (2023) 1015403.
D. Grimm, H. Schulz, M. Krüger, J.L. Cortés-Sánchez, M. Egli, A. Kraus, J. Sahana, T.J. Corydon, R. Hemmersbach, P.M. Wise, The fight against cancer by microgravity: the multicellular spheroid as a metastasis model. Intl J Mol Sci, 23 (2022) 3073.
D. Grimm, M. Wehland, T.J. Corydon, P. Richter, B. Prasad, J. Bauer, M. Egli, S. Kopp, M. Lebert, M. Krüger, The effects of microgravity on differentiation and cell growth in stem cells and cancer stem cells. Stem Cells Transl Med, 9 (2020) 882–894.
M. Braddock, From target identification to drug development in space: using the microgravity assist, Current Drug Discovery Technologies, 17 (2020) 45–56.
A. McPherson, L.J. DeLucas, Microgravity protein crystallization. Microgravity, 1 (2015) 1–20.
M.L. Gaskill, Creating New and Better Drugs with Protein Crystal Growth Experiments.
X. Mo, Y. Zhang, Z. Wang, X. Zhou, Z. Zhang, Y. Fang, Z. Fan, Y. Guo, T. Zhang, Z. Xiong, Satellite-Based On-Orbit Printing of 3D Tumor Models, Advanced Materials, 36 (2024) 2309618.
C. Urbaniak, A.C. Sielaff, K. Frey, J. Allen, N. Singh, C. Jaing, K. Wheeler, K. Venkateswaran, Detection of antimicrobial resistance genes associated with the International Space Station environmental surfaces, Sci reports, 8 (2018) 814.
J. Graf, H. Schulz, M. Wehland, T.J. Corydon, J. Sahana, F. Abdelfattah, S.L. Wuest, M. Egli, M. Krüger, A. Kraus, Omics Studies of Tumor Cells under Microgravity Conditions. Intl J Mol Sci, 25 (2024) 926.
I.N. Muhsen, A.C. Zubair, T. Niederwieser, S.K. Hashmi, Space exploration and cancer: the risks of deeper space adventures. Leukemia, 38 (2024) 1872–1875.
K. Leuraud, D.B. Richardson, E. Cardis, R.D. Daniels, M. Gillies, J.A. O’hagan, G.B. Hamra, R. Haylock, D. Laurier, M. Moissonnier, Ionising radiation and risk of death from leukaemia and lymphoma in radiation-monitored workers (INWORKS): an international cohort study. The Lancet Haematol, 2 (2015) e276–e281.
A. Wani, B. Prabhakar, P. Shende, Strategic aspects of space medicine: A journey from conventional to futuristic requisites. Space: Science & Technol, 4 (2024) 0123.
S. Maheshguru, J. Kethar, P. Rajagopal Appavu, Is Personalizing Space Medicine, Truly the Future of Space Medicine. J Student Res, 13 (2024).
M. Yamada, K. Kihira, M. Iwata, S. Takahashi, K. Inaka, H. Tanaka, I. Yoshizaki, Protein crystallization in space and its contribution to drug development. Handbook of Space Pharmaceuticals, Springer 2022, pp. 887–912.
Q.D. Tran, V. Tran, L.S. Toh, P.M. Williams, N.N. Tran, V. Hessel, Space medicines for space health. ACS Med Chem Lett, 13 (2022) 1231–1247.
T.C. Ezike, U.S. Okpala, U.L. Onoja, C.P. Nwike, E.C. Ezeako, O.J. Okpara, C.C. Okoroafor, S.C. Eze, O.L. Kalu, E.C. Odoh, Advances in drug delivery systems, challenges and future directions, Heliyon, 9 (2023).
J.M. Jaber, J. Ong, E. Waisberg, P. Sarker, N. Zaman, A. Tavakkoli, A.G. Lee, NASA’s Impact on Medical Innovation: Breakthrough Technologies from Space Research. Acta Astronautica, (2024).
A. Beheshti, J.T. McDonald, M. Hada, A. Takahashi, C.E. Mason, M. Mognato, Genomic changes driven by radiation-induced DNA damage and microgravity in human cells. Intl J Mol Sci, 22 (2021) 10507.
H. Yamamoto, K. Imai, Microsatellite instability: an update, Archives of toxicology, 89 (2015) 899–921.
C. Link, Beyond the Moon: Examining NASA’s Communication Around the Artemis II Mission. (2024).
S. Crouse, Factors Predicting Public’s Willingness to Support National Aeronautics and Space Administration’s Artemis Mission. (2024).
L. Gabel, A.-M. Liphardt, P.A. Hulme, M. Heer, S.R. Zwart, J.D. Sibonga, S.M. Smith, S.K. Boyd, Incomplete recovery of bone strength and trabecular microarchitecture at the distal tibia 1 year after return from long duration spaceflight. Sci Reports, 12 (2022) 9446.
A. Rangdal, S. Munoz, L.S. Sherman, S. Mahendrakar, Aerospace Medicine – An Evolving Field to Mitigate and Treat Organ Dysfunction Partly Caused by Premature Aging in Low Microgravity. Intl J Transl Sci, 2024 (2024) 167–176.
